Volume 26, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Mebendazole (methyl-5-benzoylbenzimidazole-2-carbamate), a new broad spectrum anthelmintic, cured 26 (74% out of 35 children with severe symptomatic trichuriasis. Repeat courses of therapy were necessary in some cases. The nine treatment failures all showed large reductions (82–99%) in egg counts. Thus, an overall satisfactory response was obtained in terms of complete parasite eradication in 74%, relief of symptoms in all, and significant reduction in worm load in the failures. In the recommended dosage of 100 mg twice daily for 3 days mebendazole failed to achieve a cure rate of 95% to 100% reported in asymptomatic individuals and those with light infections of . It is probable that measures to control diarrhea before administering mebendazole in an increased, extended, or repeated dosage schedule will achieve a higher cure rate. The drug was well tolerated and completely free from any toxic effects.


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