Volume 25, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



and mosquitoes were fed on chimpanzees carrying hepatitis B surface antigen (HB Ag) of known infectivity and pools were tested by radioimmunoassay daily for the presence of HB Ag. HB Ag continued to be detected at low levels in mosquito tissue after digestion of the blood meal. Inoculation of susceptible chimpanzees with macerated pools of mosquitoes at two intervals after digestion of the blood meal did not produce hepatitis or serologic evidence of hepatitis B virus infection. Mechanical transmission studies by interrupting feeding of from HB Ag-carrier chimpanzees and transferring them to susceptible chimpanzees did not produce hepatitis. These findings do not support the hypothesis that mosquitoes are involved in either biological or mechanical transmission of hepatitis B.


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