Volume 24, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The specificity and sensitivity of adult and larval somatic antigens and perienteric fluid of and were investigated by using a modified passive cutaneous anaphylaxis procedure in guinea pigs. Pooled sera from animals infected with low doses (0.01, 0.1, or 1.0 egg/g) were most reactive with the homologous larval antigen preparation. However, the antisera were highly reactive with this antigen only, whereas the antisera reactions could not be interpreted as being clearly positive with any of the antigen preparations. Sera from hyperinfected animals were also reactive with the homologous larval antigen. In addition, larval antigen was reactive with antiserum. The reciprocal relationship, i.e., reactivity of larval antigen with antiserum, was not apparent. In no instance did adult antigens induce reactions that could be interpreted as specific or sensitive indicators of antibody.


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