Volume 24, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The reactivity of sera from 151 confirmed human cases of infection was examined by double diffusion and indirect hemagglutination (IHA) tests chiefly against antigen because of the present unavailability of antigen. Antigens from additional parasites and other human and animal sera representing a variety of helminthic infections were used for comparison. Of 71 pre-treatment human sera, 56.3% were reactive by double diffusion test and 85.9% by IHA test (titer >1:16) with antigen. sera were also reactive with and antigens but not with antigens. Sera from other infections such as with , and were also reactive with antigen but sera from infection were not. With antigen, IHA titers in human sera are apparently not related to clinical severity of the disease; the titers remain at fairly stable levels during the course of the illness but may tend to decrease after chemotherapy. The cross-reactivities observed dictate caution in the use and interpretation of any serologic procedure for human intestinal capillariasis; nevertheless, the IHA test using antigen may be a useful additional tool in the study of infection both for clinical and epidemiologic purposes especially when the efficiency of stool examination is decreased by changes in the reproductive activity of the helminth.


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