Volume 24, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Three standard antimalarial compounds were tested against trophozoite or sporozoite induced infections of the Panamanian Achiote strain of in two species of monkeys. In (24 subjects) and (11 subjects), parasite clearance from the peripheral blood averaged 3 days after initiating chloroquine therapy (total dose of 25 mg base/kg body weight over 3 days or single dose of 10 mg base/kg). Trophozoite induced infections were cured in all of 10 and all of 6 , as indicated by the absence of relapses. Relapses did occur in 3 of 11 tests with and 3 of 5 tests with against sporozoite induced infections. Subpatent periods ranged from 38 to 111 days among intact and splenectomized hosts. This is the first chemotherapeutic evidence for the persistence of exoerythrocytic stages of in New World monkeys. Pyrimethamine (single dose of 1 mg/kg) cured trophozoite induced infections in all of five hosts. Radical cure of sporozoite induced infections was accomplished in each of six trials with chloroquine (25 mg base/kg) plus primaquine (1 mg base/kg for 14 days). The primary attack or relapse was treated. These models warrant further investigation in chemotherapy.


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