Volume 23, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The study was conducted to determine the effect of pupal chemosterilization on the susceptibility of the resulting and mosquitoes to . Mosquitoes were sterilized by exposing pupae for 1, 2 or 4 hours in 1% aqueous solution of the thioaziridine agent, -bis(1-aziridinyl)--methyl phosphinothioic amide, ENT-61585. and responded differently to pupal treatment and subsequent adult infection. Virtual complete steriligy of and was obtained after 1- and 4-hour exposure of the respective pupae to the sterilant. The difference in susceptibility between sterilized and normal mosquitoes to the malaria infection was more pronounced in than in . The overall infection rate of treated was significantly reduced over that of the control mosquitoes. In , however, a less marked effect was noticed. The infection in sterilized mosquitoes was not eliminated and sporogony of was completed with motile sporozoites in the salivary glands.


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