Volume 23, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Fluorescent precipitates were demonstrated on the cuticle and at the anal pore of microfilariae by using fluorescein isothiocyanate-labelled canine and human anti- sera. Using fluorescein conjugated rabbit anti-human globulin, these reactions were shown to be antibody mediated. The precipitating antibodies were heat and 2-mercaptoethanol stable and induced specific passive Arthus reactions in guinea pigs when antigens were injected intravenously. The titer of canine anti- antibodies correlated with the microfilaremia of the serum donor, and the prevalence of human anti- reactors in a community related to the numbers of infected dogs in the locality. Sera from people with pulmonary dirofilariasis gave high titers of anti- antibody; rabbits injected with antigens gave similar reactions, but both groups of sera cross-reacted with larvae. Sera from individuals with visceral larva migrans, diagnosed from biopsied worms, did not react with larvae. Concurrent gastrointestinal nematode infections in Aborigines did not affect the anti- fluorescent antibody test.


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