Volume 22, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Five topical ointments, each with the potential of preventing percutaneous infection by human schistosome cercariae, were tested over an 8-day period on mouse tails exposed to cercariae. In terms of worm burden reduction compared to controls, ointment CL-28A without carboset resins significantly reduced infection between 61% and 34% for 5 days; ointment CL-28 with carboset resins, between 73% and 23% for at least 6 days; ointment 25% oil extract in ether, between 100% (first 3 days post treatment) and 43% for 6 days; ointment 1 part in 4 parts CL-28A, between 100% (first 2 days post treatment) and 42% for 5 days; and ointment 1 part lapachol in 100 parts CL-28A, between 100% and 33% for 8 days.


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