1921
Volume 22, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Two strains of one from the Philippines and the other from Nigeria, were studied in 23 volunteers. In infections induced by the intravenous inoculation of parasitized blood, the peak parasitemias of from 1,400 to 27,000 per mm were attained on from the 13th to the 28th days of patent parasitemia. The median day of maximum parasitemia was 16 days. Neither strain in man readily infected mosquitoes. Transmission was obtained to six volunteers via the bites of mosquitoes infected by feeding on owl monkeys. The prepatent periods ranged from 24 to 33 days with a mean of 27.5 days. Both strains of malaria were cured by treatment with 600 mg (base) chloroquine. Treatment of the Philippine strain with quinine sulfate (30 grains per day for 5 days) was also curative. The failure of the sporozoite induced infections to relapse after treatment with blood schizontocides suggests that does not possess a fixed-tissue relapse mechanism.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1973.22.685
1973-11-01
2017-11-20
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1973.22.685
Loading
  • Accepted : 05 May 1973

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error