1921
Volume 21, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

A recently isolated human strain of (EATRO No. 1886) from Uganda was infective for mice and rhesus monkeys. Mice receiving two or three immunizing inoculations of gamma-irradiated trypanosomes were markedly protected from a challenge infection of 1,000 unirradiated organisms 1 week after immunization. Complete protection from a challenge infection was induced in 5 of 6 monkeys given six immunizing inoculations with irradiated trypanosomes. Conversely, the five unimmunized controls became patent 5 to 8 days after challenge with 10,000 unirradiated organisms, showed signs of progressive severe illness, and died between 12 and 49 days after challenge.

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/content/journals/10.4269/ajtmh.1972.21.885
1972-11-01
2019-03-21
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  • Accepted : 05 May 1972

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