1921
Volume 21, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

The antimalarial effects of minocycline, a semi-synthetic tetracycline, were evaluated in chloroquine-resistant infections. Nine volunteers infected with the Vietnam (Marks) strain were cured after each received a 7-day course of minocycline. Two additional subjects infected with the same Vietnamese strain were cured after each received a combination of minocycline and quinine. Minocycline protected 16 of 18 volunteers after challenge with mosquitoes infected with chloroquine-resistant strains of . Eleven men were protected against a single challenge by mosquitoes infected with the Cambodia (Buchanan) strain. Five of seven volunteers were protected against a single challenge by mosquitoes infected with the Vietnam (Marks) strain. No sporontocidal or gametocytocidal effects occurred in one volunteer who received a 7-day course of minocycline.

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/content/journals/10.4269/ajtmh.1972.21.857
1972-11-01
2017-11-19
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1972.21.857
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  • Accepted : 13 May 1972

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