1921
Volume 21, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Abstract

Viremia and antibody responses of chipmunks and squirrels inoculated with La Crosse (LAC) and Trivittatus (TVT) viruses were determined and compared. High level viremias were detected in 5 of 6 chipmunks (), and 4 of 5 gray squirrels () infected with LAC virus. Only 2 of 6 chipmunks infected with TVT virus developed detectable viremias. No associated clinical disease was noted. Neutralizing antibody persisted for at least 200 days in all chipmunks with LAC virus while in two of those inoculated with TVT virus it was detectable for only 140 days. Squirrels inoculated with LAC virus produced an antibody pattern similar to that in chipmunks but the titers were lower. None of the 4 gray squirrels inoculated with TVT virus had a detectable serologic response. Antibody appearing after a single inoculation of either LAC or TVT virus showed partial heterologous neutralizations of LAC, TVT, snowshoe hare (SSH), and Jamestown Canyon (JC) viruses. Transmission of LAC virus from infected chipmunks and squirrels to suckling mice was accomplished with mosquitoes.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1972.21.476
1972-07-01
2017-11-24
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1972.21.476
Loading
  • Accepted : 01 Feb 1972

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error