Volume 21, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Organs from more than 43 monkeys inoculated with 1 × 10 or 1 × 10 erythrocytes infected with chimpanzee-derived (Camp strain) and from 9 control monkeys injected with saline were studied by histologic and histochemical methods. Parasitemia at the time of death varied from 5% to 74%. Pathologic changes observed in various organs of the infected monkeys were generally mild and nonspecific. Most conspicuous were RBC's parasitized with late stages of which tended to marginate on the walls of blood vessels or to form aggregates packing, at times, the capillaries of deep organs. No intravascular thrombi were demonstrable and no tissue lesions accompanied capillary packing. Characteristic of the malaria-infected was the generally moderate response of the RE system; specifically, stimulated Kupffer's cells and swollen pulmonary endothelial cells were not very numerous. Likewise, the spleen, while enlarged, still maintained the normal structure of the red pulp. However, malpighian follicles showed marked hyperplasia and marked proliferation of immunoblasts. Otherwise, organ involvement, such as cerebral hemorrhages or glial scars, ruptured spleen, hemoglobinuric nephrosis, etc., was not observed. It is suspected that death was due to hypovolemia and shock.


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