1921
Volume 21, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Cutaneous responses to an antigenic extract (histolyticin) from were studied in normal volunteers. Of twenty-three subjects skin tested twice with 2 µg of antigen protein, one developed a positive response 24 hours following the second test. None of eight subjects tested twice with 4 µg had positive reactions. An initial 8 µg skin test produced significant local responses at 15 minutes in three subjects; 24-hour reactions were not seen. After the second 8 µg skin test, six subjects had 15-minute and four subjects had 24-hour cutaneous responses. These findings indicate that the 8 µg dose of histolyticin apparently sensitizes normal subjects and is therefore excessive for routine diagnostic or epidemiologic studies.

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/content/journals/10.4269/ajtmh.1972.21.18
1972-01-01
2017-09-23
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1972.21.18
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  • Accepted : 20 Aug 1971

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