1921
Volume 21, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Rabbits infected with develop large, spreading skin lesions. After intradermal injection of live trypanosomes there is considerable inflammation, characterized by swelling, hardness, and redness at the site of injection. Infected rabbits were treated daily with hydrocortisone and examined for skin lesions, agglutinating antibody titers, and parasitemia levels. This treatment eliminated the skin lesions, did not appreciably alter agglutinating antibody titers, and raised parasitemia levels. Treated animals also showed large weight loss and shortened survival time. Caution must therefore be used in treating human cases of African trypanosomiasis with hydrocortisone.

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/content/journals/10.4269/ajtmh.1972.21.150
1972-03-01
2017-09-26
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1972.21.150
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  • Accepted : 26 Oct 1971

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