Volume 21, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



A controlled study of the biochemical characteristics and potency of skin-test antigens was conducted on crude mycelial filtrates (1–24 weeks old) of two isolates of . Results of the study indicate that mycelial filtrates of may be specific for the detection of allergies created by this organism. A mycelial filtrate of , H-42, gave a complement-fixation reaction with serum of guinea pigs infected with . Also, immunoelectrophoretic studies indicate that and have at least one antigen in common, but that the “M” antigen of differs from that of . The crude mycelial filtrate may be fractionated by ion-exchange chromatography, producing materials which are useful in skin tests. The characteristic development of severe orchitis in male guinea pigs was also observed following intraperitoneal injections of large doses of mycelial fragments and yeast cells of .


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