Volume 20, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Intratypic variation of the nonstructural soluble complement-fixing (SCF) antigens of dengue-1 strains (Hawaii and TH-Sman) and dengue-2 strains (New Guinea C and TH-36) were examined by immunological and biophysical techniques. The SCF antigen of Hawaii could be separated from that of TH-Sman by subtle differences in CF cross reactions but by distinct differences in their relative mobilities when tested by disc-gel electrophoresis. SCF antigens of dengue-2 strains could not be distinguished by any of the methods used. We suggest that the SCF antigen is responsible for the strain variation observed in the two dengue-1 strains.


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