1921
Volume 20, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Parasitologic, serologic, pathologic, biochemical, and clinical studies were conducted in 15 chimpanzees exposed to cercariae. Numerous viable eggs were passed in the feces after a prepatent period of 5 to 8 weeks. Worm recoveries at autopsy varied considerably, but not evidence was found of a reduction in worm burdens with infections up to 17 months' duration. No consistent difference was observed in the percent recovery and location of worms in animals exposed only once or in those exposed repeatedly. Most eggs in tissues were found in the liver and large intestine, but numerous eggs were also present in the small intestine and lungs of heavily infected animals. Nearly normal hepatic blood flow was maintained via the hepatic artery even in animals with completely obstructed intrahepatic portal branches. Well-developed portasystemic collateral venous channels effectively decompressed the portal system. Hepatomegaly and severe portal fibrosis were common gross findings; variable degrees of pipe-stem fibrosis consistent with infection intensity were found. The development of pipe-stem fibrosis was particularly rapid and destructive, and hepatic lesions were more inflammatory and polymorphous with than has been reported with . Marked intestinal lesions were present in a variable and patchy segmental distribution. Glomerular lesions occurred in most chimpanzees with pipe-stem fibrosis, and the prothrombin time was abnormal in several of the more severely diseased animals. Marked hypoalbuminemia and hypergammaglobulinemia were frequent. Hypoglycemia and uremia appeared to be important factors in some infected animals. The chimpanzee was a particularly valuable model for studies on the pathogenesis of schistosomiasis japonica.

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/content/journals/10.4269/ajtmh.1971.20.850
1971-11-01
2017-11-24
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1971.20.850
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  • Accepted : 08 Jun 1971

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