Volume 20, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Pyrantel pamoate was administered orally as a single dose in a suspension or chewable tablet to 379 patients with helminth infections. Single doses of oral suspension were administered for 3 consecutive days to 89 patients. A modified Stoll technique and Richie's concentration method were performed twice before treatment and at 10 and 30 days after treatment. In a single dose of about 5 mg per pound of body weight (base activity) the cure rate for ascariasis was 96.7%; the reduction of the egg count in one case not completely cured was 98%. Significant activity was also observed against ; however, at the dosages employed, it was not superior to other agents currently in use. No significant activity was noted against . Clinical observation showed that both formulations were well tolerated by the patients. No significant changes attributable to therapy were observed in determinations of hematopoetic, liver, or renal function.


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