1921
Volume 20, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Delayed hypersensitivity phenomena in cutaneous leishmaniasis of the guinea pig, caused by , were investigated with an antigen prepared from promastigotes grown in culture. Cutaneous delayed-type hypersensitivity was shown to persist for several months after resolution of lesions. Two in vitro correlates of delayed hypersensitivity, blastoid transformation of peripheral blood lymphocytes and the inhibition of migration of peritoneal macrophages, were also positive. Macrophage inhibition persisted several months after resolution. These results suggest that immunity to this form of leishmaniasis is cell-mediated.

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/content/journals/10.4269/ajtmh.1971.20.546
1971-07-01
2017-11-24
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1971.20.546
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  • Accepted : 21 Jan 1971

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