Volume 20, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Parasitemia in night monkeys () produced by infection with the Achiote and Santa Rosa strains of was studied in normal and splenectomized animals, and in animals with and without spleens treated with azathioprine (Imuran®). Infections were produced by inoculation of blood from man in 17 (65.4%) of 26 animals, from other night monkeys in 213 (90.3%) of 236 animals, and from a Panamanian marmoset () in 1 of 2 animals. Infection was obtained in 111 (91.7%) of 121 normal monkeys, in 6 (85.7%) of 7 given azathioprine, in 15 (68.2%) of 22 splenectomized animals, and in 81 (94.2%) of 86 splenectomized animals given azathioprine. The Achiote strain has been through 56 passages and the Santa Rosa strain through 38 passages. During later passages of these strains, patent parasitemia lasted for 3 to 4 weeks, and average maximum parasitemia ranged from 15,000 to 40,000 per mm. Parasitemia was consistently higher in night monkeys, with and without spleens, treated with azathioprine, and in splenectomized animals not treated with azathioprine, than in normal animals.


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