1921
Volume 20, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Three forms of immunosuppression (splenectomy, antilymphocyte serum [ALS], and hydrocortisone) were studied in mice infected intraperitoneally with (2 × 10 parasitized erythrocytes). Splenectomy, performed 10 days before infection, impaired antibody synthesis and converted this self-limited infection to a 100% lethal infection. Antibody was measured by the indirect fluorescent-antibody (IFA) test. ALS (0.3 ml intraperitoneally every 3 days starting 6 days before infection and continuing through the infection) and hydrocortisone (4 mg intraperitoneally daily starting 1 day before infection and continuing through the infection) also impaired both antibody synthesis and recovery, but most mice eventually overcame the infection. In survivors, the appearance of antibody coincided with a decrease in parasitemia, suggesting that a humoral immunity is one of the factors essential to recovery from this malaria.

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/content/journals/10.4269/ajtmh.1971.20.389
1971-05-01
2017-09-20
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1971.20.389
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  • Accepted : 20 Nov 1970

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