1921
Volume 19, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Abstract

One hundred twenty weanling and 168 adult, male C3H mice were studied to determine the possible role of immune processes in the pathogenesis of Chagasic cardiomyopathy. Experimental myocarditis was produced with a Colombian strain of . Cyclophosphamide, 40 mg per kg, was used for immunosuppression, and it was administered in the early, the subacute, and the late subacute phases of the disease. Immunosuppression uniformly increased mortality, parasitemia, and the severity of myocarditis. Involvement and dilatation of the right ventricle dominated, without gross dilatation or hypertrophy of the left ventricle. The immune responses in Chagas' disease are beneficial to the host. Immunosuppressive therapy may be hazardous in patients with Chagas' disease.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1970.19.932
1970-11-01
2017-11-18
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1970.19.932
Loading
  • Accepted : 19 Mar 1970

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error