Volume 19, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Metronidazole (Flagyl) was used to treat 25 patients with hepatomegaly associated with intestinal infection with . Seven patients had amebic abscess of the liver, two of whom also had pulmonary amebiasis. The dosage used was 200 mg of the drug three times daily for 7 days. Response to treatment was rapid: malaise, fever, and abdominal pain were relieved after 3 days, and in most patients disappeared after 6 days of therapy. Hepatic tenderness disappeared in all patients after 3 days. Hepatomegaly regressed rapidly in all patients but did not disappear in 3 weeks in some patients. Both patients with pulmonary amebiasis improved, but in one this was transitory. There was parasitologic cure in 22 patients at the end of 3 weeks, which lasted for a further 12 weeks after treatment began, but cysts persisted in three patients. The drug was well-tolerated. Side-effects (anorexia, nausea, coated tongue, and dizziness) were mild, did not require interruption of treatment, and disappeared within 2 days after completion of therapy. We concluded that this low-dosage regime is as effective for the treatment of hepatic amebiasis as the larger doses that have been employed.


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