1921
Volume 19, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

The effect of engulfment by hamster macrophages, and of temperature, on the transformation of was investigated using NNN-cultured leptomonads, and hamster-spleen-derived Leishman-Donovan bodies. Intracellular localization of the parasities promoted transformation from leptomonad to Leishman-Donovan bodies, whereas extracellular localization promoted the reverse transformation. Temperature appeared to be a selective, rather than an inductive, factor in the transformation process. The development and maintenance of the parasite in the Leishman-Donovan body stage depended upon an intracellular localization, and upon the integrity of the macrophage, rather than the temperature of incubation.

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/content/journals/10.4269/ajtmh.1970.19.747
1970-09-01
2019-12-14
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