1921
Volume 19, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Abstract

Glucose metabolism, the prime energy-generating system of intraerythrocytic in rats, is markedly inhibited by 4,4′-diaminodiphenylsulfone (DDS) at drug concentrations that can be attained at oral doses of between 100 and 250 mg per kg. This inhibition appears to originate through interference with glucose transport at the level of the host's red-cell membrane, in contrast to a direct effect upon the intracellular parasite, since the inhibition is antagonized by raising medium glucose concentrations. DDS does not inhibit the glucose metabolism of the erythrocyte-freed parasite, and DDS also inhibits the uptake of glucose by unparasitized rat blood cells. A demonstrated ability of red cells, both parasitized and unparasitized, to concentrate DDS at the red-cell surface could help to explain the inhibition. Para-aminobenzoic acid (PABA), when incubated with DDS at equimolar concentrations, had no apparent effect upon the DDS inhibition of intraerythrocytic parasite glycolysis. The results of these investigations suggest that DDS may exert antimalarial actions by means other than the inhibition of parasite folic-acid synthesis through interfering with PABA utilization. First, the inhibition of glucose utilization by the parasite in itself might constitute an important antimalarial effect. Second, this DDS inhibition of parasite glucose metabolism may still involve interference with parasite folic-acid synthesis since the synthesis of folates by bacteria and presumably by the malaria parasite seems dependent upon an active glycolytic glucose metabolism.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1970.19.592
1970-07-01
2017-09-22
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1970.19.592
Loading
  • Accepted : 04 Jan 1970

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error