Volume 19, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The technique of blast transformation in naturally occurring disease in man, and that of macrophage migration-inhibition in experimentally induced infections in animals, were applied to the study of cellular hypersensitivity in and infections. Blast transformation of peripheral lymphocytes of patients with American cutaneous leishmaniasis occurred in the presence of leishmanin at a rate of 2% or greater, but there was no significant transformation in noninfected controls. However, in both -infected patients and presumably negative controls, antigens stimulated blast transformation. With macrophage inhibition, the converse relation was seen, with the more striking results obtained in the experimental infections. Inhibition of macrophage migration in the presence of antigen was pronounced in five of seven guinea pigs, but only one of seven -inoculated animals showed evidence of inhibition by leishmanin. This was correlated with development of strong skin-test reactions in the animals, and only slight reactions to the . Utilization of these immunologic techniques should be of value for further study of host response to parasitic infections.


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