Volume 19, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Niridazole was administered to 57 rhesus monkeys at a dosage schedule approximating the minimally curative dose for schistosomiasis mansoni of this species. This resulted in a marked depletion of the muscle glycogen stores, which was attributed in part to a reduced food intake due to anorexia produced by the drug and in part to an inhibition of phosphorylase phosphatase, activity bringing about an accumulation of active glycogen phosphorylase. Restoration of muscle glycogen levels to control values was observed about 8 days after discontinuation of drug administration.


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  • Accepted : 02 Sep 1969

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