1921
Volume 19, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Abstract

The causal prophylactic, radical curative, and blood schizontocidal activities of 7-chlorolincomycin (U-21251F) and N-demethyl-4′-pentyl-7-chlorolincomycin (U-24729A) were evaluated against infections with the Bastienellii, RO and RO/PM strains of in . Sporozoites for causal prophylactic and radical curative evaluations were derived from fed at appropriate intervals on monkeys bearing infections with the above strains. Over a wide range of tolerated doses, U-21251F effected a delay in the prepatent period in causal prophylactic studies and prolongation of relapse intervals when examined for radical cure. In the same range of doses, U-24729A effected greater lengthening of these intervals; with the largest doses, complete causal prophylaxis and radical cures were achieved in a significant fraction of cases. Prolongation of the prepatent period produced by U-24729A resulted from the effects of this agent on developing pre-erythrocytic parasites. Both U-21251F and U-24729A were as effective against challenges with sporozoites of a pyrimethamine-proguanil-resistant strain of as against challenges with a wholly drug-susceptible strain. Both compounds exhibited significant blood schizontocidal activity but were slow in clearing parasitemias. Based on these activities, clinical evaluations of the properties of U-24729A have been suggested.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1970.19.1
1970-01-01
2017-09-24
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1970.19.1
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error