Volume 18, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The temporal relations of a serum electroadsorbing factor (S. E. A. F.) that, quantitatively electroadsorbed from the serum of normal and -infected rats, were determined by a modification of the immunoelectroadsorption (I. E. A.) technique. The S. E. A. F. electroadsorbed independently of the presence of a specific antigen. It tended to increase slowly with time in normal rats. It was found to increase markedly and abruptly after the 5th day of infection, and its pattern of increase appeared to accompany the typical pattern of acute anemia and parasitemia. The S. E. A. F. remained elevated for varying periods after the resolution of infection. Its role in normal and pathophysiologic processes is presently unknown, as is its origin or identity. Its appearance interferes with the I. E. A. test, and reference is made to studies describing a resolution to this difficulty.


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