Volume 18, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



We have studied the effect of three interferon inducers (Newcastle disease virus [NDV], statolon [S], and the complex of polyriboinosinic and polyribocytidylic acids [rI:rC]) on the course of malaria in mice inoculated with sporozoites or with erythrocytic forms of . The number of parasitized cells per 10,000 erythrocytes was counted daily. Serum interferon was titrated in L-cell cultures. Parasitemia was prevented or its onset was delayed in mice treated with each inducer. Protection was greatest (survival and prevention of parasitemia) when NDV or S was given 16 to 24 hours after sporozoite inoculation. It was least (slight delay in onset of detectable parasitemia) when NDV or S was given before or after inoculation with erythrocytic forms. Mice were injected, 20 hours after inoculation of sporozoites, with diluted NDV or S, with heated S or with the supernatant of NDV-infected allantoic fluid after centrifugation at 100,000 × G. These procedures reduced both the serum-interferon-inducing and the protective effects of NDV or S. These results extend the spectrum of action of interferon inducers to a protozoon, ; they demonstrate a protective effect of interferon inducers against murine malaria; and they suggest that protection is mediated by interferons. They also show that sensitivity to the protective effect of interferon inducers varies during the development of in the mouse.


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