1921
Volume 18, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Three 7-chlorinated lincomycin derivatives exhibited curative activity against blood-inoculated infection in rhesus monkeys. Acute infections were treated by oral or subcutaneous administration for 5 consecutive days with doses ranging from 6.25 to 100 mg per kg body weight. Cures were obtained when U-21,251F (7-chlorolincomycin) and U-24,729A (7-chloro N-demethyl-4′-pentyllincomycin) were given orally at 50 mg per kg and when U-26,285A (7-chloro N-demethyllincomycin) was given at 100 mg per kg. U-24,729A and U-26,285A were also curative when given subcutaneously at 25 and 50 mg per kg, respectively. With all dosage regimens the blood was cleared of parasites 3 to 6 days after cessation of treatment. The rate of clearance of parasites did not appear to be related to dose. No side-effects due to the antibiotics were observed.

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/content/journals/10.4269/ajtmh.1969.18.485
1969-07-01
2017-11-23
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