Volume 18, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



An outbreak of St. Louis encephalitis (SLE) occurred in St. Louis County in late summer 1966. Thirteen serologically confirmed or presumptive cases were observed. The most intense SLE-virus activity was in University City, a suburban community of St. Louis, Missouri. A serologic survey conducted 3 months after the outbreak indicated a low level of antibody prevalence among the residents of University City. Most persons with SLE antibody were in the older age groups. A serologic survey conducted in a nearby community that had no reported encephalitis cases revealed antibody patterns similar to those observed in University City. Four cases of central-nervous-system infection that were investigated were related to Coxsackie virus A9 and two to herpes simplex.


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