Volume 18, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Ten spiny rats () and 12 cotton rats () were experimentally infected with VEE virus. Both are species that have been implicated as reservoirs of the virus in Panamá. VEE-virus titers were highest in the serum and throat on the 2nd day after inoculation. The values for were higher than for . The duration of viremia, usually 4 to 5 days, was similar for the two species, but virus persisted in the throat of longer than in the serum and was present up to 7 days. Neutralizing antibody appeared 3 to 5 days after inoculation and preceded the disappearance of circulating virus by one or more days. Antibody titers reached a maximum by about 18 days and remained at high levels for at least 9 months.


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