Volume 18, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Experimental infections of the spiny rat, , with viruses of the VEE complex indicated that viremia with VEE was greatest, Mucambo viremia was less, and Pixuna viremia was least. After infection with one agent, N antibodies were usually elaborated against all three viruses of the VEE complex. After reciprocal virus challenge, viremia was not demonstrated with any of the agents. However, the N- and CF-antibody responses suggested that VEE-immunized spiny rats were protected against Mucambo and Pixuna viruses, whereas Pixuna- and Mucambo-inoculated animals were incompletely protected against infection by either of the other agents. These differences appeared to be related to quantitative variation in primary immune response, which may be a function of antigenic composition of the three viruses or of host-specific properties of the Panamanian spiny rat, or both.


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