Volume 18, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The vascular permeability factor (PF) is one of the toxins derived from that may play a role in the production of cholera diarrhea. A prospective study was performed among persons in an area endemic for cholera to determine if the ability to neutralize PF could be correlated with protection against cholera. Patients with cholera and their families were skin-tested with PF immediately after admission of the first patient to the hospital, and family members were followed for 10 days for bacteriologic evidence of infection and for symptoms of cholera. Results showed no evidence that ability to neutralize vascular PF could be associated with protection against infection or modification of the symptoms of the illness. In contrast, the vibriocidal antibody titer during the acute phase of infection did correlate well with resistance to cholera.


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