1921
Volume 17, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

From Miracil D® (lucanthone), a hydroxymethyl derivative (hycanthone), can be obtained through the biological activity of the microorganism . This compound was claimed to be the antischistosomal metabolite of Miracil D and was found very active when administered to mice, hamsters, and monkeys experimentally infected with .

Clinical trials with hycanthone were performed on 52 patients with active schistosomiasis mansoni. The drug was administered, , at the dosage levels of 2 and 3 mg per kg per day with an antacid preparation, twice a day, for 5 consecutive days. In all but two patients treatment could be completed. Nausea, vomiting, anorexia, vertigo, and headache were the commonest side-effects. Therapeutic activity could be evaluated in 44 cases by repeated stool examination (four to six) or by one rectal biopsy performed at least 4 months after treatment, or by both. The percentages of patients considered as cured were 83.3 and 80.0 for the schedules of 2 and 3 mg per kg, respectively.

Laboratory and clinical data on the antischistosomal activity of hycanthone obtained so far emphasize the need for further clinical trials with this compound.

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/content/journals/10.4269/ajtmh.1968.17.743
1968-09-01
2017-09-23
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