1921
Volume 17, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Summary

The ciliated protozoon, W, was used as a test animal for determining the lethal effect of certain antimalarial drugs.

Quinacrine, proguanil, primaquine, and quinine have a definite lethal effect for . Quinacrine is lethal in amounts as small as 16 µg per ml or less, the other three being somewhat less toxic. Samples of drugs, from different lots of quinacrine and primaquine, yielded results comparable to those originally tested, and samples of primaquine from two different manufacturers yielded similar results. Chloroquine is mainly inhibitory at room temperature, but has some lethal activity when incubated at 37°C for 1 hour before the usual room-temperature incubation.

Eight other antimicrobial agents had little or no activity with the exception of chlortetracycline and minocycline. Chlortetracycline had slight lethal and moderate inhibitory activity for ; minocycline was both a strong lethal and inhibitory agent.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1968.17.359
1968-05-01
2017-09-19
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1968.17.359
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error