1921
Volume 17, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Summary

The repository sulfone 4,4′-diacetyldiaminodiphenylsulfone (DADDS) was studied for its efficacy in lepromatous leprosy. It was given in a dosage of 225 mg every 77 days to a group of 10 patients, who were matched with a group of 10 patients given oral 4,4′-diaminodiphenylsulfone (DDS, dapsone, diaphenylsulfone) in a dosage of about 100 mg per day.

Two chief criteria of therapeutic response were employed: reduction in numbers of in nasal washings and reduction in the ratio of solidly staining in skin smears (MI). Both criteria are thought to measure reduction in viability of the bacilli. By both measurements DADDS was as active as DDS. There were two deaths in the group receiving DADDS, but these were not thought to be connected with drug toxicity.

The blood level of “free” sulfones was usually less than 0.2 µg per ml in the patients receiving DADDS. The urinary output averaged 1.6 mg per 24 hours. It was estimated that the blood level remained several times higher than the minimum inhibitory concentration of DDS for .

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1968.17.192
1968-03-01
2017-09-26
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1968.17.192
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error