1921
Volume 17, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Summary

In three experiments it was shown that mice that had recovered from infection were resistant to challenging infections. Mice that were challenged 1 week after recovery appeared to be more resistant than those challenged after 5 weeks. On the other hand, mice recovered from appeared to be as susceptible as control mice when they were challenged with . There was, however, in each of three experiments a 2- to 3-day delay in the development of parasitemia in the mice recovered from infection with .

In two experiments it was evident that rats that had recovered from infection were resistant to challenge with . Resistance of rats in the converse situation is less clear since the resistance of rats recovered from infection with was obscured by extremely high parasitemia in three of 10 recovered rats.

The results of these experiments suggest that part of the immunizing mechanisms in both malaria and babesiosis are nonspecific and that the same mechanism probably pertains in both infections. It is suggested that the serum antigens in acute infections, which have been shown to be both nonspecific and immunogenic in previous work, are primarily responsible for the observed results.

The fact that mice that had recovered from infection resisted , but did not resist with does not indicate that is a more virulent parasite. In our experience is as lethal for mice as is . We believe that the apparent lack of resistance of these mice to is a manifestation other mechanisms, that is, the selection of “immunity-resistant” variants or mutants by the immunized mice.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1968.17.173
1968-03-01
2017-09-21
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1968.17.173
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error