1921
Volume 16, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

On the basis of these preliminary observations, it appears that, provided suitable temperature-controlled insectaries are available, the -A/J mouse cycle is a useful model for the evaluation of various applications of antimalarial agents including causal prophylaxis, suppressive, and curative therapy.

The short prepatent period must be considered together with the duration of persistence of the drug in blood or tissues in determining causal prophylaxis. An adequate dosage of sporozoites, which results in ready detection of exoerythrocytic stages in control and pretreated animals, is essential.

The response of sporozoite-induced infection with to antimalarial drugs resembles in several ways that seen both in and .

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/content/journals/10.4269/ajtmh.1967.16.572
1967-09-01
2017-11-19
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