1921
Volume 16, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Summary

Certain properties of Machupo virus are reported. These include presence of RNA, pH stability in the range of 6.0 to 9.0, rapid thermal inactivation at temperatures of 25°C and higher, and more effective stabilization of infectivity titers after prolonged storage (1 year) at -70°C in media containing protein supplements.

Parenteral inoculation of infant hamsters and mice with Machupo virus resulted in observable illness and death, or both, the LD and ID being roughly comparable. Inapparent infection in adult animals was detected by the presence of CF and N antibody. A variety of domestic and wild animals proved to be either resistant to the virus or susceptible only in a clinically inapparent manner. The Central American marmoset, , was found to be a clinically susceptible animal. Illness and death occurred after administration of virus subcutaneously or by scarification.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1967.16.531
1967-07-01
2017-09-20
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1967.16.531
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error