1921
Volume 16, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Summary

Subcurative doses of the antischistosomal drug tris (p-aminophenyl) carbonium chloride (TAC) to mice infected with produce three distinct changes in the parasite:

  • 1.  A reduction of glycogen in the cuticular tubercles of the males. This is followed by a flattening and subsequent disappearance of these structures.
  • 2.  Alterations in the morphologic and functional properties of the female reproductive system detectable by an staining method and leading to abnormal egg formation. In contrast to the former two changes, the effects on the female reproductive system are not specific for TAC, but are observed also after administration of subcurative doses of other antischistosomal drugs.
  • 3.  At a later stage, inhibition of acetylcholinesterase activity in the nervous system of the worm resulting in a paralysis of the adhesive organs. This coincides with the separation of the sexual pairs and a shift of the worms from the mesenteric vessels toward the liver. The drug-induced paralysis of the adhesive organs is reversed immediately on exposure of the worms to cholinergic-blocking agents .

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1967.16.500
1967-07-01
2017-09-26
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1967.16.500
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error