1921
Volume 16, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

Hycanthone is the 4-hydroxymethyl analogue and the active metabolite of lucanthone. When administered intragastrically, hycanthone is nine times more active than lucanthone against (Puerto Rican strain) in experimentally infected hamsters, and three times more active than lucanthone in mice.

The schistosomicidal activity of a single intramuscular dose of hycanthone is equal to that obtained by a 5-day regimen of intragastric medication. Conversely, lucanthone is only slightly active parenterally at subtoxic levels.

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/content/journals/10.4269/ajtmh.1967.16.487
1967-07-01
2017-09-26
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