Volume 16, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



To study whether the efficacy of chloroquine would be altered in mice by prolonged previous exposure to the drug, limited observations on blood levels of the drug as well as its antimalarial activity were studied in 2 groups of mice. One group received 0.0625% drug diet for 4 weeks while the other group received normal ration; one week after this diet treatment ended, all mice were inoculated with and divided into sub-groups of controls or subcutaneously treated animals. Chloroquine was slightly but significantly more active, at all three dose levels studied, against in mice that had previously been given the drug. Parasite counts were not different in the 2 groups of sham-dosed controls even though blood levels of chloroquine in the pretreated group were 0.1 to 0.14 γ/ml at the time of infection. Blood levels of chloroquine were similar in the 2 groups of mice 4 hours after a single subcutaneous dose of 30 mg/kg. Some possible interpretations of the differences in efficacy of the drug between the two groups are discussed. Previous exposure to chloroquine did not diminish its effectiveness.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error