1921
Volume 15, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

Turkey erythrocytes infected with were incubated with C-phosphatides, -acetate, and -fatty acids in the presence and absence of chloroquine. The C-labeled lipids were fractionated on silicic acid columns and by paper chromatography, and the radioactivity for each fraction was assayed. The drug depressed uptake of acetate into fatty acids and phospholipids in both malaria-infected and normal erythrocytes. C-stearic and palmitic acid incorporation into phospholipids of infected erythrocytes was increased by chloroquine while uptake of C-oleic acid was depressed by the drug. Incorporation of C-sodium acetate into fatty acids and phospholipids of turkey heart muscle homogenates was inhibited by the drug, and uptake of C-stearic acid into phospholipids was stimulated by chloroquine.

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/content/journals/10.4269/ajtmh.1966.15.818
1966-11-01
2017-09-20
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