1921
Volume 15, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Summary

Dogs experimentally infected with the Trinidad strain of Venezuelan equine encephalomyelitis (VEE) virus served as donor hosts for the infection of mosquitoes, 10 percent of which then transmitted the disease to guinea pigs by bite 21 days later. which fed simultaneously did not become infected.

The infection in dogs caused a frank febrile response and hemagglutination-inhibition antibody formation. Significant virus concentrations were demonstrated in the blood, brain, and testicle. Although death occurred in 6 of the 10 challenged animals, overt signs of illness were minimal. The two uninoculated dogs which were in contact with the challenged dogs became infected, but neither died.

Microscopic study of the brains disclosed various alterations, which, although not diagnostic, are considered compatible with VEE infection.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1966.15.227
1966-03-01
2017-11-18
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1966.15.227
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error