1921
Volume 15, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Summary and Conclusions

Histological skeletal muscle lesions found in the acute stage of Chagas' disease were studied in mice.

Almost all the mice infected with developed a “polymyositis” with interstitial and parenchymatous lesions. The complete histological picture of the myositis was characterized by mononuclear cell infiltration of the perimysium, waxy degeneration of fiber segments, the presence of pseudocysts and granulomatoid foci in the muscle fibers, panarteritis of small intramuscular vessels, and regeneration of the muscle fibers. The infiltrates and the phenomena of waxy degeneration were the changes most constantly seen. Not all of the damaged muscles showed a florid histological picture. In many instances there was a non-specific myositis without pseudocysts and granulomatoid foci. The waxy degeneration and the interstitial infiltration very often presented no direct relationship to the presence of parasites. In the differential diagnosis of chagasic myositis, other necrobiotic and parasitic myosites must be considered.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1966.15.135
1966-03-01
2017-11-22
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1966.15.135
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error