Volume 14, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Summary and Conclusions

A previously sensitive Chesson strain of was made resistant to chlorguanide by the stepwise use of increasing subcurative dosages.

Two volunteers medicated with CI-501 (5 mg/kg body weight) two days before challenge, and an untreated control, were exposed to the bites of infected with this resistant Chesson strain of . The two medicated volunteers as well as the control developed infections with no significant differences in the prepatent period or the clinical course.

The results indicate that CI-501 has no demonstrable effect on the Chesson strain of once resistance to the parent compound, chlorguanide, has been induced.


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