Volume 14, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The histologic alterations in mice infected with and in non-infected mice having a common circulation with infected animals were studied by means of the parabiotic technique. The experiment involved 23 exposed + unexposed pairs and 12 unexposed control pairs. The animals were sacrificed at intervals up to the seventeenth week of infection and multiple histologic features were studied.

The predominant change in the animals not directly exposed to the parasite consisted of variable degrees of lymphoreticular activation. In the lung this was manifest as prominent perivascular round cell infiltration. In the liver changes were limited to Kupffer cell hyperplasia and prominence and slight inconstant increase in portal cellularity. In the spleen lymphoreticular activation was expressed by increase in follicular size and enhancement of germinal center activity. While similar changes were noted in the control animals as a manifestation of the parabiotic state, in general, the response was less than that seen in the experimental animals.

The relationship of these changes to an immunological response of the delayed sensitivity type is discussed. The possibility is considered that alterations not seen in the unexposed parabionts are local expressions of antigen-antibody interaction or are caused by other non-transmissible factors.


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